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pentobarbital will minimize the level or influence of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.pentobarbital will lower the level or influence of bexarotene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Sodium valproate and valproic acid appear to lessen barbi